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Conservation of p53 mRNA products in bats

October 15, 2013

Alexis Mobley - Biology

Because bats live longs lives compared to other small mammals and they have not shown any incidence of cancer, my research will use the mRNA from bats to look at the p53 tumor antigen protein (the most mutated gene/protein in human cancers). I will isolate mRNA from various bat tissues, amplify the sequence, and then proceed to sequence the DNA products. The sequences that I produce will then be analyzed and compared to other small mammals as well as normal and mutated human DNA from online databases. At the conclusion of this project, I expect there to be key differences identified between bat and human p53 mRNA products. Alternatively, the mRNA may be very highly conserved.